Wonho Kim, PhD

Wonho Kim, PhD, Assistant Professor of Genetics and IBGS faculty member, received a new R35 grant from the National Institute of General Medical Sciences (NIGMS) for his project titled “Deciphering the Stepwise Regulatory Mechanisms of Genome Folding”.

The three-dimensional folding of the genome facilitates interactions between distal genomic regions, playing roles in gene transcription, DNA damage repair and DNA replication. Dysregulation of genome folding has been linked to various diseases, including cancer and developmental disorders. This proposal aims to elucidate the regulatory mechanisms of genome folding in living cells. Using genetic approaches, we will identify new factors involved in genome folding and determine the specific process within the genome folding regulated by these factors. Collectively, our studies aim to unveil novel molecular mechanisms governing genome folding, offering a deeper understanding of its contributions to disease states.